 Gene description for HSP90AA1 |
| Gene name |
heat shock protein 90 alpha family class A member 1 |
| Gene symbol |
HSP90AA1 |
| Other names/aliases |
EL52
HEL-S-65p
HSP86
HSP89A
HSP90A
HSP90N
HSPC1
HSPCA
HSPCAL1
HSPCAL4
HSPN
Hsp103
Hsp89
Hsp90
LAP-2
LAP2 |
| Species |
Homo sapiens |
| Experiment description of studies that identified HSP90AA1 in Melanoma cells |
| 1
|
| Experiment ID | 453 |
| Identified molecule | protein
|
| Extracellular vesicle type | Exosomes |
| MISEV | EVs |
| Identification method | Mass spectrometry
|
| PubMed ID |
22635005 
|
| Organism | Homo sapiens |
| Experiment description | Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. |
| Authors | Peinado H, Alecković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. |
| Journal name |
Nat Med
|
| Publication year | 2012 |
| Sample | Melanoma cells |
| Sample name | B16-F10, SK-MEL-202, SK-MEL035, SK-MEL-265 |
| Isolation/purification methods | - |
| Flotation density | - |
| Molecules identified in the study | Protein |
| Methods used in the study | Mass spectrometry |
| EV-TRACK |
EV120019: EV-METRIC:44%, 44%, 44%
|
|
|
| 2
|
| Experiment ID | 496 |
| Identified molecule | mRNA
|
| Extracellular vesicle type | Microvesicles |
| MISEV | EVs |
| Identification method | Microarray
|
| PubMed ID |
23344721
|
| Organism | Homo sapiens |
| Experiment description | miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles. |
| Authors | Bolukbasi MF, Mizrak A, Ozdener GB, Madlener S, Ströbel T, Erkan EP, Fan JB, Breakefield XO, Saydam O. |
| Journal name |
Mol Ther Nucleic Acids
|
| Publication year | 2012 |
| Sample | Melanoma cells |
| Sample name | Primary malignant melanoma cells (0105) |
| Isolation/purification methods | - |
| Flotation density | - |
| Molecules identified in the study | mRNA |
| Methods used in the study | Microarray |
| EV-TRACK |
-
|
|
|
| 3
|
| Experiment ID | 497 |
| Identified molecule | mRNA
|
| Extracellular vesicle type | Microvesicles |
| MISEV | EVs |
| Identification method | Microarray
|
| PubMed ID |
23344721
|
| Organism | Homo sapiens |
| Experiment description | miR-1289 and Zipcode-like Sequence Enrich mRNAs in Microvesicles. |
| Authors | Bolukbasi MF, Mizrak A, Ozdener GB, Madlener S, Ströbel T, Erkan EP, Fan JB, Breakefield XO, Saydam O. |
| Journal name |
Mol Ther Nucleic Acids
|
| Publication year | 2012 |
| Sample | Melanoma cells |
| Sample name | Primary malignant melanoma cells (0664) |
| Isolation/purification methods | - |
| Flotation density | - |
| Molecules identified in the study | mRNA |
| Methods used in the study | Microarray |
| EV-TRACK |
-
|
|
|
| 4
|
| Experiment ID | 621 |
| Identified molecule | protein
|
| Extracellular vesicle type | Extracellular vesicles |
| MISEV | EVs |
| Identification method | Mass spectrometry [LTQ]
|
| PubMed ID |
27894104
|
| Organism | Homo sapiens |
| Experiment description | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. |
| Authors | Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. |
| Journal name |
Oncotarget
|
| Publication year | 2016 |
| Sample | Melanoma cells |
| Sample name | SK-MEL-2 |
| Isolation/purification methods | Differential centrifugation
Polymer-based precipitation
Ultracentrifugation |
| Flotation density | - |
| Molecules identified in the study | Protein |
| Methods used in the study | Mass spectrometry [LTQ] |
| EV-TRACK |
-
|
|
|
| 5
|
| Experiment ID | 622 |
| Identified molecule | protein
|
| Extracellular vesicle type | Extracellular vesicles |
| MISEV | EVs |
| Identification method | Mass spectrometry [LTQ]
|
| PubMed ID |
27894104
|
| Organism | Homo sapiens |
| Experiment description | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. |
| Authors | Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. |
| Journal name |
Oncotarget
|
| Publication year | 2016 |
| Sample | Melanoma cells |
| Sample name | SK-MEL-28 |
| Isolation/purification methods | Differential centrifugation
Polymer-based precipitation
Ultracentrifugation |
| Flotation density | - |
| Molecules identified in the study | Protein |
| Methods used in the study | Mass spectrometry [LTQ] |
| EV-TRACK |
-
|
|
|
| 6
|
| Experiment ID | 623 |
| Identified molecule | protein
|
| Extracellular vesicle type | Extracellular vesicles |
| MISEV | EVs |
| Identification method | Mass spectrometry [LTQ]
|
| PubMed ID |
27894104
|
| Organism | Homo sapiens |
| Experiment description | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. |
| Authors | Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. |
| Journal name |
Oncotarget
|
| Publication year | 2016 |
| Sample | Melanoma cells |
| Sample name | SK-MEL-5 |
| Isolation/purification methods | Differential centrifugation
Polymer-based precipitation
Ultracentrifugation |
| Flotation density | - |
| Molecules identified in the study | Protein |
| Methods used in the study | Mass spectrometry [LTQ] |
| EV-TRACK |
-
|
|
|
| 7
|
| Experiment ID | 986 |
| Identified molecule | protein
|
| Extracellular vesicle type | Exosomes/Microvesicles |
| MISEV | EVs |
| Identification method | Mass spectrometry
|
| PubMed ID |
25261472
|
| Organism | Homo sapiens |
| Experiment description | Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. |
| Authors | Liang Y, Eng WS, Colquhoun DR, Dinglasan RR, Graham DR, Mahal LK. |
| Journal name |
J Biol Chem.
|
| Publication year | 2014 |
| Sample | Melanoma cells |
| Sample name | SK-MEL-5 |
| Isolation/purification methods | Differential centrifugation
Ultracentrifugation |
| Flotation density | - |
| Molecules identified in the study | Protein |
| Methods used in the study | Mass spectrometry
Western blotting |
| EV-TRACK |
EV140188: EV-METRIC:22%
|
|
|
| 8
|
| Experiment ID | 3211 |
| Identified molecule | protein
|
| Extracellular vesicle type | Small extracellular vesicles |
| MISEV | Small EVs |
| Identification method | Western blotting
|
| PubMed ID |
34957415
|
| Organism | Homo sapiens |
| Experiment description | Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism |
| Authors | García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H. |
| Journal name |
Nat Cancer
|
| Publication year | 2021 |
| Sample | Melanoma cells |
| Sample name | SK-MEL-147 |
| Isolation/purification methods | Differential centrifugation
Ultracentrifugation |
| Flotation density | - |
| Molecules identified in the study | Protein |
| Methods used in the study | Western blotting
Flow cytometry |
| EV-TRACK |
-
|
|
|
